Psenen^tm1.1Guiq
Targeted Allele Detail

Summary

• Symbol: Psenen^tm1.1Guiq
• Name: presenilin enhancer gamma secretase subunit; targeted mutation 1.1, Guiquan Chen
• MGI ID: MGI:7311992
• Synonyms: Pen-2^f
• Gene: Psenen Location: Chr7:30261290-30263052 bp, - strand Genetic Position: Chr7, 18.6 cM, cytoband A3
• Alliance: Psenen^tm1.1Guiq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273599
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxp site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site downstream of the gene. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 2-4 floxed. (J:273599)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psenen Mutation: 14 strains or lines available

References

• Original: J:273599 Cheng S, et al., Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors. J Neurosci. 2019 Mar 20;39(12):2195-2207
• All: 4 reference(s)