Cops6^tm1.1Fshe
Targeted Allele Detail

Summary

• Symbol: Cops6^tm1.1Fshe
• Name: COP9 signalosome subunit 6; targeted mutation 1.1, Farah Sheikh
• MGI ID: MGI:7310462
• Synonyms: Csn6^fl
• Gene: Cops6 Location: Chr5:138159364-138162246 bp, + strand Genetic Position: Chr5, 76.97 cM, cytoband G1
• Alliance: Cops6^tm1.1Fshe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326270
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP flanked neomycin selection cassette was inserted upstream of exon 1 and a third loxP site was inserted downstream of exon 10. The neomycin selection cassette was removed via cre-mediated recombination leaving exons 4-10 floxed. (J:326270)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cops6 Mutation: 15 strains or lines available

References

• Original: J:326270 Liang Y, et al., Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Clin Invest. 2021 Jun 1;131(11)
• All: 1 reference(s)