Wwc1^tm1.2Rlh
Targeted Allele Detail

Summary

• Symbol: Wwc1^tm1.2Rlh
• Name: WW, C2 and coiled-coil domain containing 1; targeted mutation 1.2, Richard L Huganir
• MGI ID: MGI:7310430
• Gene: Wwc1 Location: Chr11:35729227-35871354 bp, - strand Genetic Position: Chr11, 21.96 cM
• Alliance: Wwc1^tm1.2Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178552
• Parent Cell Line: MCI (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette. (J:178552)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wwc1 Mutation: 55 strains or lines available

References

• Original: J:178552 Makuch L, et al., Regulation of AMPA receptor function by the human memory-associated gene KIBRA. Neuron. 2011 Sep 22;71(6):1022-9
• All: 3 reference(s)