Arhgef12^Tvrm266
Chemically induced Allele Detail

Summary

• Symbol: Arhgef12^Tvrm266
• Name: Rho guanine nucleotide exchange factor 12; translational vision research model 266
• MGI ID: MGI:7309977
• Gene: Arhgef12 Location: Chr9:42875138-43017069 bp, - strand Genetic Position: Chr9, 24.14 cM, cytoband B
• Alliance: Arhgef12^Tvrm266 page

Mutation origin

• Strain of Origin: B6.Cg-Crb1^rd8/Pjn

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• This ENU-induced c.71T>A point mutation results in an early stop signal at codon 24 (p.L24*) (J:326080)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arhgef12 Mutation: 89 strains or lines available

References

• Original: J:326080 Weatherly SM, et al., Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1rd8 mouse model. PLoS Genet. 2022 Jun;18(6):e1009798
• All: 1 reference(s)