Kcnt1^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcnt1^em1Gpt
• Name: potassium channel, subfamily T, member 1; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:7301170
• Synonyms: Kcnt1^em1Cflox
• Gene: Kcnt1 Location: Chr2:25753807-25808285 bp, + strand Genetic Position: Chr2, 18.27 cM
• Alliance: Kcnt1^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and a second loxP site downstream of exon 32 (in reference to ENSMUST00000037580.12) using sgRNAs and ssODN templates with CRISPR/Cas9 technology. (J:322801)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnt1 Mutation: 70 strains or lines available

References

• Original: J:322801 Liu Y, et al., The Slack Channel Deletion Causes Mechanical Pain Hypersensitivity in Mice. Front Mol Neurosci. 2022;15:811441
• All: 2 reference(s)