Clcnka^em1Cjc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Clcnka^em1Cjc
• Name: chloride channel, voltage-sensitive Ka; endonuclease-mediated mutation 1, Chih-Jen Cheng
• MGI ID: MGI:7294295
• Synonyms: Clcnk1^fl
• Gene: Clcnka Location: Chr4:141111922-141126017 bp, - strand Genetic Position: Chr4, 73.94 cM
• Alliance: Clcnka^em1Cjc page

Mutation origin

• Strain of Origin: C57BL/6JNarl

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR/cas9 mediated recombination inserted loxP sites in introns 2 and 15. (J:316474)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clcnka Mutation: 21 strains or lines available

References

• Original: J:316474 Lin MH, et al., Impairment in renal medulla development underlies salt wasting in Clc-k2 channel deficiency. JCI Insight. 2021 Oct 22;6(20):e151039
• All: 1 reference(s)