Appl2^tm1.1Smoc
Targeted Allele Detail

Summary

• Symbol: Appl2^tm1.1Smoc
• Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; targeted mutation 1.1, Shanghai Model Organisms Center
• MGI ID: MGI:7294210
• Synonyms: Appl2 KO
• Gene: Appl2 Location: Chr10:83435897-83484602 bp, - strand Genetic Position: Chr10, 41.29 cM
• Alliance: Appl2^tm1.1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226873
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 5 was flanked with loxP sites. An FRT-flanked neomycin resistance cassette was inserted upstream of the loxP sites. Cre-mediated recombination removed exon 5. (J:226873)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Appl2 Mutation: 27 strains or lines available

References

• Original: J:226873 Mao L, et al., Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway. Cell Biosci. 2014;4(1):60
• All: 1 reference(s)