Ptgs2^em1Cye
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ptgs2^em1Cye
• Name: prostaglandin-endoperoxide synthase 2; endonuclease-mediated mutation 1, Yelin Chen
• MGI ID: MGI:7293337
• Gene: Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
• Alliance: Ptgs2^em1Cye page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a deletion of exon 1. Western blot confirmed absence of protein. (J:325946)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgs2 Mutation: 72 strains or lines available

References

• Original: J:325946 Zhou J, et al., NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury. Cell Rep. 2022 Mar 29;38(13):110557
• All: 1 reference(s)