Klf1^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Klf1^em1Smoc
• Name: Kruppel-like transcription factor 1 (erythroid); endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:7290860
• Synonyms: Klf1^{em1(flox)Smoc}
• Gene: Klf1 Location: Chr8:85628611-85631920 bp, + strand Genetic Position: Chr8, 41.3 cM
• Alliance: Klf1^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: These mice carry loxP sites flanking exon 2 of Klf1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Klf1 gene. (J:238766, J:349564)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf1 Mutation: 20 strains or lines available

References

• Original: J:349564 Zhang F, et al., An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption. Nature. 2023 Oct;622(7984):834-841
• All: 2 reference(s)