H2-Ab1^g7-em4Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: H2-Ab1^g7-em4Smoc
• Name: histocompatibility 2, class II antigen A, beta 1; endonuclease-mediated mutation 4, Shanghai Model Organisms Center
• MGI ID: MGI:7290143
• Synonyms: H2-Ab1^em4Smoc
• Gene: H2-Ab1 Location: Chr17:34482201-34488392 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-Ab1^g7-em4Smoc page

Mutation origin

• Strain of Origin: NOD.Cg-Prkdc^scid Il2rg^em1Smoc/Smoc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1 H2-AA H2-Eb1 H2-Eb2 H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the M-NSG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I. (J:238766)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2-Ab1 Mutation: 81 strains or lines available

References

• Original: J:238766 Shanghai Model Organisms Center, Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China. MGI Direct Data Submission. 2017
• All: 1 reference(s)