Gt(ROSA)26Sor^{em55(Vil1-CYP3A4,-tdTomato)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em55(Vil1-CYP3A4,-tdTomato)Smoc}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 55, Shanghai Model Organisms Center
• MGI ID: MGI:7290064
• Synonyms: Gt(ROSA)26Sor^{em1(Gut-CYP3A4-IRES-tdTomato)Smoc}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em55(Vil1-CYP3A4,-tdTomato)Smoc} page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{em55(Vil1-CYP3A4,-tdTomato)Smoc} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CYP3A4 (1576)

  Cyp3a13

  (MGI:88610)

• Mutation details: Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 Humanized sequence mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article. (J:238766)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:238766 Shanghai Model Organisms Center, Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China. MGI Direct Data Submission. 2017
• All: 1 reference(s)