Cd40lg^tm1.1Lorc
Targeted Allele Detail

Summary

• Symbol: Cd40lg^tm1.1Lorc
• Name: CD40 ligand; targeted mutation 1.1, Lori R Covey
• MGI ID: MGI:7287883
• Synonyms: CD40Ldelta5
• Gene: Cd40lg Location: ChrX:56257503-56269402 bp, + strand Genetic Position: ChrX, 31.21 cM
• Alliance: Cd40lg^tm1.1Lorc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320462
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Using BAC RP23-153G22, a 178 bp sequence (CCCTCCCTCTCTCCCATCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCACACACACACACACACACACAGACATACACACACACACACACACACACACAGACACACACACACACACACACACACACACACACACGGAGTCAGGCTATTGTTGGCTGGT), containing most of the tandem repeats in the B and C sites of the 3' UTR stability element, was deleted. The loxP site flanked neomycin resistance gene cassette that was inserted downstream of the gene was removed through subsequent Cre-mediated recombination. (J:320462)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd40lg Mutation: 12 strains or lines available

References

• Original: J:320462 Narayanan B, et al., A Posttranscriptional Pathway of CD40 Ligand mRNA Stability Is Required for the Development of an Optimal Humoral Immune Response. J Immunol. 2021 Jun 1;206(11):2552-2565
• All: 1 reference(s)