Cd40lgtm1.1Lorc
Targeted Allele Detail
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Symbol: |
Cd40lgtm1.1Lorc |
Name: |
CD40 ligand; targeted mutation 1.1, Lori R Covey |
MGI ID: |
MGI:7287883 |
Synonyms: |
CD40Ldelta5 |
Gene: |
Cd40lg Location: ChrX:56257503-56269402 bp, + strand Genetic Position: ChrX, 31.21 cM
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Alliance: |
Cd40lgtm1.1Lorc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:320462
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Modified regulatory region) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Using BAC RP23-153G22, a 178 bp sequence (CCCTCCCTCTCTCCCATCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCACACACACACACACACACACAGACATACACACACACACACACACACACACAGACACACACACACACACACACACACACACACACACGGAGTCAGGCTATTGTTGGCTGGT), containing most of the tandem repeats in the B and C sites of the 3' UTR stability element, was deleted. The loxP flanked neomycin resistance gene cassette that was inserted downstream of the gene was removed through subsequent cre-mediated recombination.
(J:320462)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cd40lg Mutation: |
14 strains or lines available
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Original: |
J:320462 Narayanan B, et al., A Posttranscriptional Pathway of CD40 Ligand mRNA Stability Is Required for the Development of an Optimal Humoral Immune Response. J Immunol. 2021 Jun 1;206(11):2552-2565 |
All: |
1 reference(s) |
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