Ern1^tm2.1Yli
Targeted Allele Detail

Summary

• Symbol: Ern1^tm2.1Yli
• Name: endoplasmic reticulum to nucleus signalling 1; targeted mutation 2.1, Yong Liu
• MGI ID: MGI:7286487
• Synonyms: Ern1^S724A
• Gene: Ern1 Location: Chr11:106285476-106378678 bp, - strand Genetic Position: Chr11, 69.14 cM, cytoband E1
• Alliance: Ern1^tm2.1Yli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325540
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: The AGT codon for serine 724 residue within exon 17 was substituted with the GCT codon for alanine. An FRT-flanked neomycin cassette was inserted downstream of exon 17 and was removed via flp-mediated recombination. (J:325540)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ern1 Mutation: 58 strains or lines available

References

• Original: J:325540 Li Y, et al., Phosphorylation at Ser(724) of the ER stress sensor IRE1alpha governs its activation state and limits ER stress-induced hepatosteatosis. J Biol Chem. 2022 Apr 29;298(6):101997
• All: 1 reference(s)