Gt(ROSA)26Sor^{em1(CAG-Nlrc5)Khog}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-Nlrc5)Khog}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Kristin A Hogquist
• MGI ID: MGI:7286188
• Synonyms: Nlrc5-stop^flox
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-Nlrc5)Khog} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: CRISPR-targeting inserted a CAG promoter driving expression of the mouse coding sequence preceded by a floxed stop cassette (CAG-LoxP-STOP-LoxP-Nlrc5-WPRE-pA). (J:317587)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:317587 Georgiev H, et al., Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells. Nat Commun. 2021 Apr 16;12(1):2308
• All: 1 reference(s)