Gem^tm1.1Hokh
Targeted Allele Detail

Summary

• Symbol: Gem^tm1.1Hokh
• Name: GTP binding protein overexpressed in skeletal muscle; targeted mutation 1.1, Hitoshi Okamura
• MGI ID: MGI:7284830
• Synonyms: gem^-
• Gene: Gem Location: Chr4:11704457-11714752 bp, + strand Genetic Position: Chr4, 5.34 cM
• Alliance: Gem^tm1.1Hokh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325323
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The vector containing the neo cassette was targeted to the Ge, gene genomic sequence to replace the sequence encoding the G2 domain in exons 1 and 2. Loss of Gem expression in the homozygous mice was confirmed histologically by in situ hybridization. (J:325323)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gem Mutation: 17 strains or lines available

References

• Original: J:325323 Matsuo M, et al., A light-induced small G-protein gem limits the circadian clock phase-shift magnitude by inhibiting voltage-dependent calcium channels. Cell Rep. 2022 May 24;39(8):110844
• All: 1 reference(s)