Twist2^tm1.1Rhs
Targeted Allele Detail

Summary

• Symbol: Twist2^tm1.1Rhs
• Name: twist basic helix-loop-helix transcription factor 2; targeted mutation 1.1, Rho H Seong
• MGI ID: MGI:7284432
• Synonyms: Twist2^flox
• Gene: Twist2 Location: Chr1:91729183-91775750 bp, + strand Genetic Position: Chr1, 46.24 cM
• Alliance: Twist2^tm1.1Rhs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325253
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and FRT-flanked puromycin selection cassette was inserted into Not! site of exon 1 and a second loxP site downstream of exon 1. Flp-mediated recombination removed the selection cassette and left exon 1 floxed. (J:325253)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Twist2 Mutation: 10 strains or lines available

References

• Original: J:259455 Oh S, et al., Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes. Cell Death Differ. 2016 Nov 1;23(11):1804-1814
• All: 3 reference(s)