Anpep^em#Dfox
Endonuclease-mediated Allele Detail

Summary

• Symbol: Anpep^em#Dfox
• Name: alanyl aminopeptidase, membrane; endonuclease-mediated mutation, David A Fox
• MGI ID: MGI:7284427
• Synonyms: Cd13^-
• Gene: Anpep Location: Chr7:79471551-79497958 bp, - strand Genetic Position: Chr7, 45.19 cM
• Alliance: Anpep^em#Dfox page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• Mutation details: CRISPR/Cas9 technology was used to introduce a premature termination codon in exon 2, from position 79841638 to 79842251. Three lines that introduced premature termination codons predicted to result in nonsense-mediated mRNA decay and absence of protein were obtained. (J:325206)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Anpep Mutation: 84 strains or lines available

References

• Original: J:325206 Tsou PS, et al., Soluble CD13 induces inflammatory arthritis by activating the bradykinin receptor B1. J Clin Invest. 2022 Jun 1;132(11):e151827
• All: 1 reference(s)