Bard1^tm9.1Rjbr
Targeted Allele Detail

Summary

• Symbol: Bard1^tm9.1Rjbr
• Name: BRCA1 associated RING domain 1; targeted mutation 9.1, Richard J Baer
• MGI ID: MGI:7284164
• Synonyms: Bard1-K132N
• Gene: Bard1 Location: Chr1:71066690-71142300 bp, - strand Genetic Position: Chr1, 35.67 cM
• Alliance: Bard1^tm9.1Rjbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94077
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting vector contains a loxP-flanked neomycin inserted into intron 3 and a lysine to asparagine amino acid substitution at position 132 (K132N; AAG to AAC) inserted into exon 4. The mutation corresponds to the human tumor-associated mutation, K140N and found in two patients with colorectal carcinoma or uterine corpus endometrial carcinoma. Cre-mediated recombination removed the neo cassette. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bard1 Mutation: 54 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)