Hoxb8^{em1(flpo)Vabr}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hoxb8^{em1(flpo)Vabr}
• Name: homeobox B8; endonuclease-mediated mutation 1, Victoria Abraira
• MGI ID: MGI:7282054
• Gene: Hoxb8 Location: Chr11:96172731-96176141 bp, + strand Genetic Position: Chr11, 59.82 cM
• Alliance: Hoxb8^{em1(flpo)Vabr} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Hoxb8^{em1(flpo)Vabr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hoxb8 (MGI:96189)

• Mutation details: CRISPR/cas9 endonuclease-mediated genome editing was used to insert a codon optimized T2A-Flpo sequence just before the stop codon in the 3' UTR. Endogenous Hox8b gene function is not disrupted. (J:339474)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxb8 (mouse) Summary of all recombinase alleles driven by Hoxb8. Alliance mouse Hoxb8 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hoxb8 Mutation: 8 strains or lines available

References

• Original: J:339474 Bohic M, et al., A new Hoxb8FlpO mouse line for intersectional approaches to dissect developmentally defined adult sensorimotor circuits. Front Mol Neurosci. 2023;16:1176823
• All: 1 reference(s)