Wdfy3^{Gt(OSTGST_5258_D3)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Wdfy3^{Gt(OSTGST_5258_D3)Lex}
• Name: WD repeat and FYVE domain containing 3; gene trap insertion OSTGST_5258_D3, Lexicon Pharmaceuticals
• MGI ID: MGI:7280943
• Synonyms: Alfy GT
• Gene: Wdfy3 Location: Chr5:101980822-102217787 bp, - strand Genetic Position: Chr5, 48.95 cM
• Alliance: Wdfy3^{Gt(OSTGST_5258_D3)Lex} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238334
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv x C57BL/6

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap cassette inserted into exon 2. The full length transcript is not produced in homozygous mutant mice, and antibodies directed against the NH3- or COOH-terminus of the encoded protein confirmed that full length protein was not detectable in brain lysates derived from homozygous mutant mice. (J:238334)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdfy3 Mutation: 212 strains or lines available

References

• Original: J:238334 Dragich JM, et al., Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain. Elife. 2016 Sep 20;5:e14810
• All: 2 reference(s)