Mkrn3^tm1.1Ywang
Targeted Allele Detail

Summary

• Symbol: Mkrn3^tm1.1Ywang
• Name: makorin, ring finger protein, 3; targeted mutation 1.1, Yuexiang Wang
• MGI ID: MGI:7280779
• Synonyms: Mkrn3^fl
• Gene: Mkrn3 Location: Chr7:62067341-62069887 bp, - strand Genetic Position: Chr7, 34.37 cM
• Alliance: Mkrn3^tm1.1Ywang page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309040
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 1. The neomycin selection cassette was removed via flp-mediated recombination leaving exon 1 floxed. (J:309040)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mkrn3 Mutation: 29 strains or lines available

References

• Original: J:309040 Li K, et al., E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer. J Exp Med. 2021 Aug 2;218(8)
• All: 1 reference(s)