Idh2^tm1Wencc
Targeted Allele Detail

Summary

• Symbol: Idh2^tm1Wencc
• Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial; targeted mutation 1, Wen-Chien Chou
• MGI ID: MGI:7280672
• Synonyms: Idh2^R172K
• Gene: Idh2 Location: Chr7:79744594-79765140 bp, - strand Genetic Position: Chr7, 45.43 cM
• Alliance: Idh2^tm1Wencc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:322711
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: A G-to-A mutation was introduced in exon 4 to change arginine codon 172 (AGG) to lysine (AAG) (p.R172K) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 5. This mutation is associated with myeloid and lymphoid malignancies when found in conjunction with mutations in other genes. (J:322711)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Idh2 Mutation: 145 strains or lines available

References

• Original: J:322711 Chen TC, et al., Oncogenesis induced by combined Phf6 and Idh2 mutations through increased oncometabolites and impaired DNA repair. Oncogene. 2022 Mar;41(11):1576-1588
• All: 1 reference(s)