Gt(ROSA)26Sor^{em8(CAG-Venus*,-Katushka2S)Murr}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em8(CAG-Venus*,-Katushka2S)Murr}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 8, Stephen Murray
• MGI ID: MGI:7279150
• Synonyms: TLR-7, TLR7
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em8(CAG-Venus*,-Katushka2S)Murr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J-Gt(ROSA)26Sor^em7Mvw/Mvw

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutation: Insertion
• Mutation details: This knockin is a gene editing reporter with a Venus sequence interrupted by the insertion of a 47bp sgRNA sequence that replaces 9bp of sequence (GAGCGCACC, encoding Glu, Arg and Thr), followed by Katushka2S encoded in the +2 frame such that Venus expression indicates HDR and Katushka2S expression indicates NHEJ. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1062 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 2 reference(s)