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Lrrc8aem1Tjj
Endonuclease-mediated Allele Detail
Summary
Symbol: Lrrc8aem1Tjj
Name: leucine rich repeat containing 8A VRAC subunit A; endonuclease-mediated mutation 1, Thomas J Jentsch
MGI ID: MGI:7278860
Synonyms: LRRC8A-3xHA, Lrrc8aHA
Gene: Lrrc8a  Location: Chr2:30127781-30153802 bp, + strand  Genetic Position: Chr2, 21.41 cM
Alliance: Lrrc8aem1Tjj page
Mutation
origin
Strain of Origin:  C57BL/6NCrl
Mutation
description
Allele Type:    Endonuclease-mediated (Epitope tag)
Mutation:    Insertion
 
Mutation detailsMice express an LRRC8A-3xHA fusion protein from the endogenous Lrrc8a promoter. The 3xHA tag was inserted by CRISPR genome editing technology. (J:265881)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrrc8a Mutation:  51 strains or lines available
References
Original:  J:265881 Luck JC, et al., LRRC8/VRAC anion channels are required for late stages of spermatid development in mice. J Biol Chem. 2018 Jul 27;293(30):11796-11808
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory