Vdr^tm1.1Mtz
Targeted Allele Detail

Summary

• Symbol: Vdr^tm1.1Mtz
• Name: vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 1.1, Daniel Metzger
• MGI ID: MGI:7277807
• Synonyms: VDR^Gem, Vdr^L304H
• Gene: Vdr Location: Chr15:97752308-97806177 bp, - strand Genetic Position: Chr15, 53.85 cM
• Alliance: Vdr^tm1.1Mtz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222898
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting construct introduced the point mutations resulting in the amino acid substitution of leucine with histidine at position 304 (L304H). Cre-mediated recombination removed the floxed neomycin resistance cassette within intron 9. (J:222898)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vdr Mutation: 35 strains or lines available

References

• Original: J:222898 Huet T, et al., A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects. Cell Rep. 2015 Feb 3;10(4):516-26
• All: 1 reference(s)