Erap1^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Erap1^em1Smoc
• Name: endoplasmic reticulum aminopeptidase 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:7277682
• Synonyms: Erap1^-, Erap1-KO
• Gene: Erap1 Location: Chr13:74787692-74841324 bp, + strand Genetic Position: Chr13, 40.48 cM, cytoband C1
• Alliance: Erap1^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Using CRISPR/Cas9 technology, exon 3 of Erap1 gene was deleted to generate Erap1 knockout mice. (J:324249)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Erap1 Mutation: 59 strains or lines available

References

• Original: J:324249 Niu Y, et al., Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination. Diabetes. 2022 May 1;71(5):921-933
• All: 1 reference(s)