Tnfaip3^em2Stgr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tnfaip3^em2Stgr
• Name: tumor necrosis factor, alpha-induced protein 3; endonuclease-mediated mutation 2, Shane T Grey
• MGI ID: MGI:7275311
• Synonyms: Tnfaip3^I207L
• Gene: Tnfaip3 Location: Chr10:18876658-18891158 bp, - strand Genetic Position: Chr10, 8.08 cM
• Alliance: Tnfaip3^em2Stgr page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: Using an sgRNA (targeting TGACAATGATGGGTCTTCTGAGG) and an ssODN template (CTCCTCAGAGCTGAAACTCACCCAGGGAACCTAGAAACTCTCTGAGGCACCTCACCTGAAATGACAATGAGGGGTCTTCTGAGAATGTTGCTGAGGACAAATATGTGGATTTCTTCCAGGGAATTGTACTGAAGTCCACTTCGGGCTGCA) with CRISPR/Cas9 technology, isoleucine codon 207 (ATC) was changed to leucine (CTC) (c.619A>C, p.I207L). (J:283545)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfaip3 Mutation: 44 strains or lines available

References

• Original: J:283545 Zammit NW, et al., Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity. Nat Immunol. 2019 Oct;20(10):1299-1310
• All: 1 reference(s)