Tnfaip3^em1Stgr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tnfaip3^em1Stgr
• Name: tumor necrosis factor, alpha-induced protein 3; endonuclease-mediated mutation 1, Shane T Grey
• MGI ID: MGI:7275310
• Synonyms: Tnfaip3^C243Y
• Gene: Tnfaip3 Location: Chr10:18876658-18891158 bp, - strand Genetic Position: Chr10, 8.08 cM
• Alliance: Tnfaip3^em1Stgr page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: Using an sgRNA (targeting GGGATATCTGTAACACTCC) and an ssODN template (CACTGTCCTTCAGGGTCACCAGGGGTACAAAGTGCTGGCTGTCATAGCCTAGGACGATGGGATATCTGTAATACTCCTGAGCAGGCCAGTGAAGAGGCAGATAAATCCCACCCACTTTCAAAGGAGCAAAATTGGAACCAGATTCCAAAC) with CRISPR/Cas9 technology, cysteine codon 243 (TGT) was changed to tyrosine (TAT) (c.728G>A, p.C243Y). (J:283545)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfaip3 Mutation: 44 strains or lines available

References

• Original: J:283545 Zammit NW, et al., Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity. Nat Immunol. 2019 Oct;20(10):1299-1310
• All: 1 reference(s)