Atg16l1^em1Babr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Atg16l1^em1Babr
• Name: autophagy related 16 like 1; endonuclease-mediated mutation 1, The Babraham Institute
• MGI ID: MGI:7266398
• Synonyms: ATG16L1 K490A
• Gene: Atg16l1 Location: Chr1:87683730-87720150 bp, + strand Genetic Position: Chr1, 44.44 cM
• Alliance: Atg16l1^em1Babr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of lysine with alanine at position 490 (K490A). (J:324069)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atg16l1 Mutation: 44 strains or lines available

References

• Original: J:324069 Goodwin JM, et al., GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis. Sci Adv. 2021;7(40):eabj2485
• All: 1 reference(s)