Rubcn^tm1.2Ttkh
Targeted Allele Detail

Summary

• Symbol: Rubcn^tm1.2Ttkh
• Name: RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein; targeted mutation 1.2, Tetsuo Takehara
• MGI ID: MGI:7266370
• Synonyms: Rubicon^-
• Gene: Rubcn Location: Chr16:32642072-32698121 bp, - strand Genetic Position: Chr16, 23.38 cM
• Alliance: Rubcn^tm1.2Ttkh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273327
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 6 sequences were flanked by two loxP sites and an frt-flanked neomycin selection cassette. The FRT-neo-FRT sequence was removed via FLP-mediated recombination and exon 6 was removed via Cre-mediated recombination in the germline. (J:273327)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rubcn Mutation: 39 strains or lines available

References

• Original: J:273327 Nakamura S, et al., Suppression of autophagic activity by Rubicon is a signature of aging. Nat Commun. 2019 Feb 19;10(1):847
• All: 3 reference(s)