Ddc^tm1.2Rhrs
Targeted Allele Detail

Summary

• Symbol: Ddc^tm1.2Rhrs
• Name: dopa decarboxylase; targeted mutation 1.2, Raymond Harris
• MGI ID: MGI:7266281
• Synonyms: Ddc^delta7
• Gene: Ddc Location: Chr11:11764101-11848144 bp, - strand Genetic Position: Chr11, 7.09 cM, cytoband A1-A4
• Alliance: Ddc^tm1.2Rhrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324028
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 7. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette and left exon 7 floxed. Cre-mediated recombination removed exon 7. (J:175630)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddc Mutation: 128 strains or lines available

References

• Original: J:175630 Zhang MZ, et al., Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice. J Clin Invest. 2011 Jul 1;121(7):2845-54
• All: 2 reference(s)