Bard1^tm6.1Rjbr
Targeted Allele Detail

Summary

• Symbol: Bard1^tm6.1Rjbr
• Name: BRCA1 associated RING domain 1; targeted mutation 6.1, Richard J Baer
• MGI ID: MGI:7265153
• Synonyms: Bard1-D488H
• Gene: Bard1 Location: Chr1:71066690-71142300 bp, - strand Genetic Position: Chr1, 35.67 cM
• Alliance: Bard1^tm6.1Rjbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94077
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: : The targeting vector contains a loxP-flanked neomycin inserted into intron 6 and an aspartic acid to histidine amino acid substitution at position 488 (D488H; GAT to CAT) inserted into exon 6. Cre-mediated recombination removed the neomycin cassette.The mutation corresponds to human tumor-associated missense mutations in the ankyrin domain that disrupts BARD1 recognition of H4K20me0 (histone H4 unmethylated at lysine 20). (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bard1 Mutation: 54 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)