Rimbp2^tm1.1Sud
Targeted Allele Detail

Summary

• Symbol: Rimbp2^tm1.1Sud
• Name: RIMS binding protein 2; targeted mutation 1.1, Thomas C Sudhof
• MGI ID: MGI:7265067
• Synonyms: RIM-BP2 KO
• Gene: Rimbp2 Location: Chr5:128834855-129030550 bp, - strand Genetic Position: Chr5, 67.91 cM
• Alliance: Rimbp2^tm1.1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227659
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 10 followed by frt-flanked neomycin (neo) and puromycin (puro) resistance cassettes, and a second loxP site downstream of exon 10. Cre-mediated recombination in the germline resulted in the deletion of exon 10 and the resistance cassettes. (J:227659)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rimbp2 Mutation: 47 strains or lines available

References

• Original: J:227659 Acuna C, et al., RIM-BPs Mediate Tight Coupling of Action Potentials to Ca(2+)-Triggered Neurotransmitter Release. Neuron. 2015 Sep 23;87(6):1234-47
• All: 3 reference(s)