Gpr183^tm1.1Scla
Targeted Allele Detail

Summary

• Symbol: Gpr183^tm1.1Scla
• Name: G protein-coupled receptor 183; targeted mutation 1.1, Stefano Casola
• MGI ID: MGI:7265060
• Synonyms: EBI2-fl-EGFP
• Gene: Gpr183 Location: Chr14:122189963-122202607 bp, - strand Genetic Position: Chr14, 65.86 cM
• Alliance: Gpr183^tm1.1Scla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251437
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: The single coding exon was flanked by loxP sites. An EGFP reporter cassette, was inserted downstream of the floxed coding exon. Upon Cre-mediated recombination, the coding exon of the gene is replaced by the EGFP minigene that fails to express the endogenous encoded protein. A, frt-flanked neomycin resistance cassette was eliminated in vivo by crossing to a FLPe deleter strain. (J:251437)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr183 Mutation: 27 strains or lines available

References

• Original: J:251437 Wanke F, et al., EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells. Cell Rep. 2017 Jan 31;18(5):1270-1284
• All: 3 reference(s)