Ttll4^{tm1b(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Ttll4^{tm1b(EUCOMM)Wtsi}
• Name: tubulin tyrosine ligase-like family, member 4; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:7265059
• Gene: Ttll4 Location: Chr1:74700804-74740991 bp, + strand Genetic Position: Chr1, 38.54 cM
• Alliance: Ttll4^{tm1b(EUCOMM)Wtsi} page
• IMPC: Ttll4 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:323874
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The L1L2_gt2 cassette was inserted at position 74724047 of Chromosome 1 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 74725815. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:323874)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttll4 Mutation: 71 strains or lines available

References

• Original: J:323874 Wu HY, et al., TTLL1 and TTLL4 polyglutamylases are required for the neurodegenerative phenotypes in pcd mice. PLoS Genet. 2022 Apr;18(4):e1010144
• All: 1 reference(s)