Rora^tm1.1Cdon
Transgenic Allele Detail

Summary

• Symbol: Rora^tm1.1Cdon
• Name: RAR-related orphan receptor alpha; targeted mutation 1.1, Chen Dong
• MGI ID: MGI:7265040
• Synonyms: Roralpha^fl
• Gene: Rora Location: Chr9:68561068-69295528 bp, + strand Genetic Position: Chr9, 37.45 cM
• Alliance: Rora^tm1.1Cdon page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:323837
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Transgene description

• Transgene Type: Transgenic (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6 and an FRT-flanked neomycin resistance cassette and second loxP site were inserted downstream of exon 6. The selection cassette was removed via flp-mediated recombination leaving exon 6 floxed. (J:323837)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rora Mutation: 43 strains or lines available

References

• Original: J:323837 Chi X, et al., RORalpha is critical for mTORC1 activity in T cell-mediated colitis. Cell Rep. 2021 Sep 14;36(11):109682
• All: 1 reference(s)