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Cant1tm1.2Aros
Targeted Allele Detail
Nomenclature
Symbol: Cant1tm1.2Aros
Name: calcium activated nucleotidase 1; targeted mutation 1.2, Antonio Rossi
MGI ID: MGI:7264674
Synonyms: Cant1-
Gene: Cant1  Location: Chr11:118297115-118309912 bp, - strand  Genetic Position: Chr11, 83.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:282272
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J x 129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA G to A transition at position 905 (c.G905A) resulting in an arginine to histidine substitution at amino acid 302 (p.R302H) was introduced in exon 4. In addition, an FRT-flanked neomycin selection cassette and loxP site were inserted upstream of exon 3 and a second loxP site was inserted downstream of mutated exon 4. The selection cassette was removed via flp-mediated recombination and cre-mediated recombination deleted exons 3 and 4. Real-time PCR confirmed absence of mRNA in skin. (J:282272)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cant1 Mutation:  21 strains or lines available
References
Original:  J:282272 Paganini C, et al., Calcium activated nucleotidase 1 (CANT1) is critical for glycosaminoglycan biosynthesis in cartilage and endochondral ossification. Matrix Biol. 2019 Aug;81:70-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/09/2022
MGI 6.21
The Jackson Laboratory