Shank3^tm6.1Gfng
Targeted Allele Detail

Summary

• Symbol: Shank3^tm6.1Gfng
• Name: SH3 and multiple ankyrin repeat domains 3; targeted mutation 6.1, Guoping Feng
• MGI ID: MGI:7264480
• Gene: Shank3 Location: Chr15:89383826-89444464 bp, + strand Genetic Position: Chr15, 44.96 cM
• Alliance: Shank3^tm6.1Gfng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:285373
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 1316 (encoding the PDZ domain) of the gene were flanked with loxP sites and an frt-flanked neomycin selection cassette. The neomycin selection cassette was removed in the germline via FLP1-mediated recombination. (J:285373)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shank3 Mutation: 87 strains or lines available

References

• Original: J:285373 Orefice LL, et al., Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models. Cell. 2019 Aug 8;178(4):867-886.e24
• All: 2 reference(s)