Egln1^tm1Jomy
Targeted Allele Detail

Summary

• Symbol: Egln1^tm1Jomy
• Name: egl-9 family hypoxia-inducible factor 1; targeted mutation 1, Johanna Myllyharju
• MGI ID: MGI:7264333
• Synonyms: Hif-p4h-2^loxP
• Gene: Egln1 Location: Chr8:125635326-125676063 bp, - strand Genetic Position: Chr8, 72.86 cM
• Alliance: Egln1^tm1Jomy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:323229
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 3 and a third loxP site was inserted downstream of exon 3 via homologous recombination. (J:323229)

Expression

In Mice Carrying this Mutation:

373 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egln1 Mutation: 23 strains or lines available

References

• Original: J:323229 Rosendahl AH, et al., Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia. J Biol Chem. 2022 Mar 2;298(4):101787
• All: 1 reference(s)