Tcof1^tm1Zhng
Targeted Allele Detail

Summary

• Symbol: Tcof1^tm1Zhng
• Name: treacle ribosome biogenesis factor 1; targeted mutation 1, Jing Zhang
• MGI ID: MGI:7263351
• Gene: Tcof1 Location: Chr18:60946827-60982043 bp, - strand Genetic Position: Chr18, 34.41 cM
• Alliance: Tcof1^tm1Zhng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:322607
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP site was inserted in intron 1 and intron 2 flanking exon1 followed by neo and CD and an additional loxP. The cre mediated recombination will result in either exon 1 deleted null allele, or generate a conditional null allele with the exon 1 flanked by loxP. (J:322607)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcof1 Mutation: 109 strains or lines available

References

• Original: J:322607 Wen Z, et al., Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras(Q61R/+) mice. Leukemia. 2022 Jan 26
• All: 1 reference(s)