Gfap^em1Eko
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gfap^em1Eko
• Name: glial fibrillary acidic protein; endonuclease-mediated mutation 1, Eryan Kong
• MGI ID: MGI:7263294
• Synonyms: GFAP-C291A
• Gene: Gfap Location: Chr11:102778162-102791368 bp, - strand Genetic Position: Chr11, 66.48 cM, cytoband D
• Alliance: Gfap^em1Eko page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Using CRISPR/Cas9 technology, Gfap gene C291A mutation was introduced in the fertilized C57BL/6 eggs in vitro fertilization with sperm of PPT1-KI mice Ppt1^tm1.1Abm. (J:303993)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfap Mutation: 46 strains or lines available

References

• Original: J:303993 Yuan W, et al., GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2022261118
• All: 1 reference(s)