Sost^tm1Yako
Targeted Allele Detail

Summary

• Symbol: Sost^tm1Yako
• Name: sclerostin; targeted mutation 1, Yasuhiro Kobayashi
• MGI ID: MGI:7263279
• Synonyms: Sost^Green, Sost-ZsGreen, Spst^-
• Gene: Sost Location: Chr11:101853284-101857841 bp, - strand Genetic Position: Chr11, 65.48 cM, cytoband D
• Alliance: Sost^tm1Yako page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294900
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: By homologous recombination in the ES cells the 184-bp Sost coding sequence exon 1 was replaced with ZsGreen coding sequence, which was fused to 24 nucleotides after the Sost start codon (J:294900)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sost Mutation: 31 strains or lines available

References

• Original: J:294900 Koide M, et al., Sclerostin expression in trabecular bone is downregulated by osteoclasts. Sci Rep. 2020 Aug 13;10(1):13751
• All: 2 reference(s)