Adgrl3^tm1.2Sud
Targeted Allele Detail

Summary

• Symbol: Adgrl3^tm1.2Sud
• Name: adhesion G protein-coupled receptor L3; targeted mutation 1.2, Thomas C Sudhof
• MGI ID: MGI:7263076
• Synonyms: Lphn3 KO
• Gene: Adgrl3 Location: Chr5:81167985-81972980 bp, + strand Genetic Position: Chr5, 42.62 cM
• Alliance: Adgrl3^tm1.2Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272910
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to insert a double hemagglutinin (HA) tag into the 3'end of exon 6 of the gene. A loxP site, followed by a frt-flanked neomycin resistance cassette, was inserted upstream of exon 6, and a second loxP site was inserted downstream. Cre and FLP-mediated recombination in the germline removed the neomycin resistance cassette and the HA-tagged exon 6. (J:272910)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgrl3 Mutation: 98 strains or lines available

References

• Original: J:272910 Sando R, et al., Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins. Science. 2019 Feb 22;363(6429)
• All: 2 reference(s)