Fgf13^tm1.1Bcgen
Targeted Allele Detail

Summary

• Symbol: Fgf13^tm1.1Bcgen
• Name: fibroblast growth factor 13; targeted mutation 1.1, Biocytogen LLC
• MGI ID: MGI:7262994
• Synonyms: Fgf13^fl
• Gene: Fgf13 Location: ChrX:58107505-58613431 bp, - strand Genetic Position: ChrX, 33.31 cM
• Alliance: Fgf13^tm1.1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251087
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 322 bp upstream of exon 3 and an FRT-flanked neomycin selection cassette and second loxP site were inserted 226 bp downstream of exon 3. The neomycin cassette was removed via flp-mediated recombination leaving exon 3 floxed. (J:251087)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf13 Mutation: 11 strains or lines available

References

• Original: J:251087 Wang X, et al., Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles. J Mol Cell Cardiol. 2017 Mar;104:63-74
• All: 9 reference(s)