Dgcr2^tm1Ktani
Targeted Allele Detail

Summary

• Symbol: Dgcr2^tm1Ktani
• Name: DiGeorge syndrome critical region gene 2; targeted mutation 1, Kenji Tanigaki
• MGI ID: MGI:7262985
• Synonyms: Dgcr2 KO
• Gene: Dgcr2 Location: Chr16:17658219-17709592 bp, - strand Genetic Position: Chr16, 11.05 cM, cytoband A-B1
• Alliance: Dgcr2^tm1Ktani page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:323337
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• The exon 1 of the Dgcr2 gene was replaced by an EGFP-Neo cassette by homologous recombination. (J:323337)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dgcr2 Mutation: 24 strains or lines available

References

• Original: J:323337 Kimoto S, et al., Selective overexpression of Comt in prefrontal cortex rescues schizophrenia-like phenotypes in a mouse model of 22q11 deletion syndrome. Transl Psychiatry. 2012 Aug 7;2:e146
• All: 1 reference(s)