Vdr^tm3.1Ska
Targeted Allele Detail

Summary

• Symbol: Vdr^tm3.1Ska
• Name: vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 3.1, Shigeaki Kato
• MGI ID: MGI:7262738
• Synonyms: VDR deltaAF-2, VDRdeltaAF2
• Gene: Vdr Location: Chr15:97752308-97806177 bp, - strand Genetic Position: Chr15, 53.85 cM
• Alliance: Vdr^tm3.1Ska page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:323213
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: The mutation is a deletion of the genomic sequences encoding the 12C-terminal amino acids and the introduction of two stop codons after codon 410. An Spe I restriction site was also engineered to allow detection of the mutant locus. A loxP flanked neomycin selection cassette was removed via Cre-mediated recombination. (J:323213)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vdr Mutation: 35 strains or lines available

References

• Original: J:323213 Vangoitsenhoven R, et al., Effect of a transcriptional inactive or absent vitamin D receptor on beta-cell function and glucose homeostasis in mice. J Steroid Biochem Mol Biol. 2016 Nov;164:309-317
• All: 3 reference(s)