Cd47^tm1.1Mato
Targeted Allele Detail

Summary

• Symbol: Cd47^tm1.1Mato
• Name: CD47 antigen (Rh-related antigen, integrin-associated signal transducer); targeted mutation 1.1, Takashi Matozaki
• MGI ID: MGI:7262735
• Synonyms: CD47^f
• Gene: Cd47 Location: Chr16:49671691-49732799 bp, + strand Genetic Position: Chr16, 31.23 cM
• Alliance: Cd47^tm1.1Mato page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254342
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and an FRT-flanked neomycin resistance cassette was inserted upstream of exon 1 and a second loxP site was inserted downstream of exon 1. The neomycin cassette was removed via flp-mediated recombination leaving exon 1 floxed. (J:254342)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd47 Mutation: 32 strains or lines available

References

• Original: J:254342 Saito Y, et al., SIRPalpha(+) dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen. Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10151-E10160
• All: 4 reference(s)