Rag1^em2Dgs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rag1^em2Dgs
• Name: recombination activating 1; endonuclease-mediated mutation 2, David G Schatz
• MGI ID: MGI:7262704
• Synonyms: R1.KR
• Gene: Rag1 Location: Chr2:101468627-101479846 bp, - strand Genetic Position: Chr2, 53.88 cM
• Alliance: Rag1^em2Dgs page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 mediated recombination induced the K233R point mutation into Rag1 and introduced a HindIII site that does not affect the amino acid sequence of the protein to facilitate genotyping. (J:323218)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rag1 Mutation: 132 strains or lines available

References

• Original: J:323218 Beilinson HA, et al., The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination. J Exp Med. 2021 Oct 4;218(10):e20210250
• All: 1 reference(s)