Lifr^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Lifr^tm1.1Arte
• Name: LIF receptor alpha; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:7261362
• Synonyms: Lifr^flox
• Gene: Lifr Location: Chr15:7120095-7226970 bp, + strand Genetic Position: Chr15, 3.46 cM
• Alliance: Lifr^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:323095
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP upstream of exon 4 and an FRT-flanked puromycin resistance cassette with a 3' loxP site downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exon 4 floxed. (J:323095)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lifr Mutation: 58 strains or lines available

References

• Original: J:323095 Yao F, et al., A targetable LIFR-NF-kappaB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis. Nat Commun. 2021 Dec 17;12(1):7333
• All: 2 reference(s)