Ano1^tm1Bvs
Targeted Allele Detail

Summary

• Symbol: Ano1^tm1Bvs
• Name: anoctamin 1, calcium activated chloride channel; targeted mutation 1, Boris V Skryabin
• MGI ID: MGI:7261222
• Gene: Ano1 Location: Chr7:144142286-144305711 bp, - strand Genetic Position: Chr7, 88.85 cM
• Alliance: Ano1^tm1Bvs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:323038
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (129/Sv x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 7 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 7 via homologous recombination. Western blot analysis detected reduced expression in blood vessels from heterozygous mice. (J:323038)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano1 Mutation: 61 strains or lines available

Notes

ES cells = CV19

References

• Original: J:323038 Matchkov VV, et al., A paradoxical increase of force development in saphenous and tail arteries from heterozygous ANO1 knockout mice. Physiol Rep. 2020 Nov;8(22):e14645
• All: 1 reference(s)